Sensory Gating Endophenotype Based on Its Neural Oscillatory Pattern and Heritability Estimate
نویسندگان
چکیده
منابع مشابه
Sensory gating endophenotype based on its neural oscillatory pattern and heritability estimate.
CONTEXT The auditory sensory gating deficit has been considered a leading endophenotype in schizophrenia. However, the commonly used index of sensory gating, P50, has low heritability in families of people with schizophrenia, raising questions about its utility in genetic studies. We hypothesized that the sensory gating deficit may occur in a specific neuronal oscillatory frequency that reflect...
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One of the most consistent electrophysiological deficits reported in the schizophrenia literature is the failure to inhibit, or properly gate, the neuronal response to the second stimulus of an identical pair (i.e., sensory gating). Although animal and invasive human studies have consistently implicated the auditory cortex, prefrontal cortex and hippocampus in mediating the sensory gating respo...
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The ratio of magnetoencephalogram-recorded brain responses occurring 50ms after paired clicks (S2-evoked M50/S1-evoked M50) serves as a measure of sensory gating. An abnormally large ratio is commonly found in schizophrenia. Whether this abnormality indicates impaired gating is debated. Using event-related oscillations the present study sought to elucidate processes contributing to the phenomen...
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ژورنال
عنوان ژورنال: Archives of General Psychiatry
سال: 2008
ISSN: 0003-990X
DOI: 10.1001/archpsyc.65.9.1008